Trying to get clean LSBs from anything more than a 12 bit ADC is *DIFFICULT*
it's not difficult, it just requires more narrow bandwidth. You can apply low pass filter with desired bandwidth and get more clean LSB. Of course it will require more time for measurement, because low frequency signal measurement requires longer measurement time.
In order to measure real DC (0 Hz) with maximum precision, you will need infinite time for measurement

But there is no real DC in real world, any DC is actually AC with very low frequency

Regarding to the noise, our real world full of noise, for example Brownian motion is a noise. Electron motion also noisy (electrons behavior very similar to gas molecules), so you will not be able to get clean LSB for wide bandwidth ADC, because there is no clean DC in real world.