At these power levels, with reasonably designed equipment, it shouldn't be too fragile and decent stuff should have some SWR protection at least to 2:1. Amps built for lab use have complete SWR protection for gross mismatch. You can abuse the heck out of Mini Circuits amps in this class. (ask me how I know).
The worst case voltage that you can have with a completely open load is 2x of your nominal peak voltage- an SWR of infinity.
The doomsday scenario is what Ham's do at legal limit power. At 1500 W into 50 ohms, you have 387 volts peak when matched and near 800 on a complete mismatch. (P=V^2/R, Vpk=1.414*Vrms)). This is a lot and break down coax, fry finals, etc.
At 10W, the matched peak is 31.6V and the worst case is 63v. If you can sample and rectify your output voltage- nothing fancy, you can kill PA bias on a problem. It might make sense to trip at SWR of 2+. This would be peak volts of (1+(SWR-1/SWR+1)) or 42V (+33%). Not terrible and easy to implement. You could bring this high SWR signal fault back to your PS and kill it there or use a load switch or relay.
Most QRP gear (<5-10W) doesn't bother with SWR protection. Standard 100W Ham gear does. Elekraft makes high quality HF transceivers and generously post their schematics. Their K2 is a classic 10W rig and has an optional 100W PA. The 10W version does nothing, the 100W does a bit which you can study in their schematics. A lot of solid-state equipment doesn't even see the peaks above, they're transformer coupled and generate power at lower Z's and step up at the output.
You can solve a lot of problems with a mechanical interlock switch that won't let power go to AMP without a connector on the output.
I did a project for biologists that used a little RF amp like this to boost a little 10 dBm transmitter to 30 dBm to transmit ISM control signals at 433 MHz. It probably wasn't strictly legal but it was a late fix when we needed more signal because of dense vegetation that I hadn't taken into account in the link budgets. It was always used in the boonies for bird tracking and for short periods. It was assembled in the field and attached to an antenna by a preoccupied graduate student. There was a big red note on it that said "don't run without antenna connected". We never cooked an amp over the couple years it ran. I bought a spare that I probably still have.
Have fun.