I don't know which package is the most popular, but I also don't think the question can be answered without narrowing down what you're really interested in. E.g., if you only want to simulate a circuit, there are applications that just do that. If you're going to turn the circuit into a physical design on a printed circuit board (PCB), there are packages that integrate circuit design and PCB design in one application. A single, independent, consulting EE is probably going to gravitate toward a different solution than the one chosen by a team at a large corporation (more expensive, more collaboration tools, possibly integrating circuit design + PCB design + simulation).