I take it that when you say "generic" SMPS you are talking about one NOT designed specifically for audio use. These supplies are probably designed for profit more than for performance. So the designers probably put in little output filtering or abnormal operating mode suppression.
There is no such thing as a "silent" SMPS. I have used a boost converter to create the HV for a couple of tube-based guitar products and the noise generated by the switching can be pernicious and infectious. The noise finds its way into other circuits by conduction through the SMPS output and radiation from any/all inductors and conductors that handle the high voltage.
Any suggestions/arguments that the noise is easily filtered out because the frequencies involved are above human hearing are fallacious. Even if the supply is working at a nominal 100KHz, its regulation will use frequencies that extend all the way down through the audible range, all the way to a few tens of Hz. The feedback paths in the regulator will be modulated with a significant amount of random or not-so-random noise so as to also modulate, not only the output voltage but also the timing of high voltage/current switched signals with audible noise frequencies. These high voltage signals will be broadcast through the air to every conductor within the unit, thus carrying the audible modulation there as well. High frequency noise as well as the audio-frequency modulation noise conducted via the SMPS output will not only be directly injected into any circuit that it supplies but also take advantage of that power network as an antenna system to further infect everything else in range.
So, what to do? The solutions are the usual.
Stop the noise at the generator:
1 - try to keep control of the sources by quelling unwanted PS operating modes such as undampened control loops, sub-harmonic oscillation, etc.
2 - try to keep radiated magnetic fields low with toroidal inductors.
3 - shield the entire (or at least the noisiest part of the) power supply with a shield can, ground planes, etc.
4 - filter outputs with R-C or L-C networks at the point where the output leaves the above shield can.
Kill the noise at the loads:
5 - apply more filtering on supply rails at the point of use using R-C's, L-C's, ferrite beads. This can be applied on a module, channel or individual load basis.
If there is ANY high pitched audible noise directly to be heard from a purchased SMPS then its not for you. That noise is either from a switcher which is operating from a too-low frequency or it is operating in a bad sub-harmonic mode. That noise will infect any amplifier that is not designed to withstand it.
The most paranoid measures must be applied for high-gain amplifiers. Put them in their own shield boxes, on separate PCBs, more filtering, whatever you can do to isolate it from inevitable noise pickup.
That's all I can say.