I just finished a project where the front and rear panels are in 1/8" aluminum. My nibbler won't go quite that thick. I used a step drill for the holes, filing to clean things up (or drilling from both sides).
For the big rectangular hole I needed for my display, I used a hole at each corner, and then a jigsaw with a metal cutting blade. It's fast and pretty clean. There's always some filing required as well.
tim