No, ISP (in system programming) is a hardware feature. There is no in system boot program.
On some AVRs it is possible to change the fuses in a way so no further ISP programming is possible. ISP needs the reset pin, and when activating normal I/O on the reset pin it no longer function as reset pin, and therefore ISP no longer works. If the particular AVR has no other programming means (JTAG, bootloader, HV programming) no other program can ever be written into it.