I think I've heard that PADS supports sub-nets, i.e., chaining parts in exact or constrained sequence. Altium has From-Tos, though I haven't seen them used.
All programs, as far as I know, by default, treat all pins in a node as exactly equivalent. As long as those pins are connected by some copper, it doesn't matter how, or where, or with what size. (Okay, most/all programs support design rules for trace size, but that's probably done as a separate check, not when checking connectivity.)
As for whether it really matters -- it depends. If you place components out of order, you can get high frequency effects, like stub transmission lines and peaks and valleys in the impedance or frequency response. This only shows up when the frequency is very high (length of stub > wavelength/10, say), and when the impedance ratio is very different (system impedance very low or very high relative to the trace impedance: switching circuits being the most common example, as impedances of \$\sim 1 \Omega\$ are common, and impedances under \$ 20 \Omega\$ are hard to construct).
That shouldn't be an "or", actually. More precisely, the ratio of impedance (let r = Z / Zo; the ratio of impedance is then: (r + 1/r) / 2) multiplies the critical stub length, so that, say, for an operating frequency of 1MHz and an impedance ratio of 20, you need stub length < 1m.