A typical laptop certainly wont be safe to handle with high voltage on its chassis. Some even have conductive cases. If anything it would be more dangerous than floating a conventional scope which is well known to be occasionally lethal.
OTOH, if you are only working with low voltages (under +/-50V from ground) in low energy circuits (i.e. no high current supercaps or big battery banks), at low frequency, it can provide isolation.
However if you get anything wrong, or forget to unplug that laptop PSU, you could not only blow the scope but the laptop hosting it as well. Assuming you avoid injury, if you've got a recent full backup you are only out the cost of both + the time to acquire a replacement, reinstall all your applications and restore your data. If not you'll be cursing the day you chose to be cheap and didn't get an isolated differential probe!