A simple discrete preamplifier might contain two CE stages followed by a CC (follower) stage, with feedback from the output emitter to the input emitter.
Without feedback, it will have predominantly 2nd order distortion at reasonable levels (due to asymmetry, as mentioned above), with 3rd order predominant at high levels (it grows faster than the 2nd order).
So, quantitatively, there will be a difference from an op amp with differential stages, where the 2nd order distortion is reduced by the symmetry, before the feedback is applied.
(Of course, real op amps often have nasty crossover distortion in the output stage, which should be avoided in the design.)
The interesting question, which involves perception as well as measurement, is why high-order distortion products are "nasty", as commonly believed.
My personal opinion, based on various readings and measurements on RF systems, is that the odd-order distortion is bad, since when you take a real musical waveform (with a very complex spectrum) and mess it up with 3rd-order intermodulation, distortion products occur between the fundamental frequencies of the musical notes and sound like "mud" (to use a technical term).
Harmonics themselves are relatively innocuous, since the musical notes are not pure tones (e.g., 440 Hz), but the fundamental and many harmonics at integer multiples thereof.
Think of a solo flute, whose notes are rich in harmonics, and the relative magnitude of the harmonics is under some control of the skilled player.
IM and THD are measurement techniques, but both distortions result from the same non-linear behavior of the amplifier under test.
I once mentioned in an audio forum that third-order distortion was bad, and someone agreed, since he had looked up the 3rd harmonic (1320 Hz) of 440 Hz and couldn't find it in a table of equal-tempered scale frequencies, the closest being a tempered E at 1318.51 Hz. Of course, this is because the equal-tempered scale is an engineering approximation applied to music to fit everything into the black and white keys on a piano.