I recently got a 64GB IDE/PATA drive for my ancient Gateway Win XP machine. It works fine, no special configuration needed, but since XP doens't have native TRIM support it will wear more quickly then running on a recent OS. Data transfer rates doubled from my old 5400rpm drive, random access time is infinitely faster. It makes the laptop usable again for not much money and it's only the fan noise now that can be heard.
Months ago, I upgraded an old, fast, Dell WinXP desktop machine by swapping the SATA HD for an SSD. Also, no special configuration was needed. That machine really benefited from this upgrade, much more so than the IDE/PATA SSD upgrade on my Gateway.