Author Topic: Covid 19 Vaccine  (Read 936 times)

0 Members and 1 Guest are viewing this topic.

Offline SilverSolder

  • Super Contributor
  • ***
  • Posts: 2500
  • Country: 00
Covid 19 Vaccine
« on: March 17, 2020, 07:19:35 pm »

How fast can the life sciences work?


March 16, 2020
SEATTLE (AP) — U.S. researchers gave the first shot to the first person in a test of an experimental coronavirus vaccine Monday -- leading off a worldwide hunt for protection even as the pandemic surges.

https://www.wgbh.org/news/national-news/2020/03/16/coronavirus-vaccine-test-opens-as-us-volunteer-gets-1st-shot
 

Offline vad

  • Regular Contributor
  • *
  • Posts: 63
  • Country: us
Re: Covid 19 Vaccine
« Reply #1 on: March 17, 2020, 07:47:28 pm »
Chief scientist on Trump’s task force said it will take 12-18 months. My hope, they will find a way to cut corners, and maybe we will see “deployable” vaccine by fall. They are already doing that, by going straight to phase 1 clinical trials, bypassing animal testing.
 
The following users thanked this post: SilverSolder

Online Bud

  • Super Contributor
  • ***
  • Posts: 4214
  • Country: ca
Re: Covid 19 Vaccine
« Reply #2 on: March 17, 2020, 08:17:47 pm »
Frankly, 18 months is what pretty much all other medical specialists are estimating , not only that genius in us government.
Facebook-free life and Rigol-free shack.
 
The following users thanked this post: Mortymore

Offline Stray Electron

  • Frequent Contributor
  • **
  • Posts: 972
Re: Covid 19 Vaccine
« Reply #3 on: March 17, 2020, 08:22:39 pm »
   12 to 18 months is an incredibly fast time to market for anything medical in the US. Usually the time is measured in decades. As the previous poster pointed out, they're skipping animal testing and have started human testing. But it will take months to see which treatments are effective and which aren't. They hope to have those answers by about August or September. After that they think it will take 6 months to start manufacturing and probably another 6 months before they have enough doses to begin to inoculate large numbers of people.
 

Offline vad

  • Regular Contributor
  • *
  • Posts: 63
  • Country: us
Re: Covid 19 Vaccine
« Reply #4 on: March 17, 2020, 10:51:33 pm »
Also note that influenza vaccine is reformulated twice a year. So obviously flu vac does not go through the 12-18 month long clinical trials and production cycle. Otherwise it will become obsolete, due to flu mutation, before vaccine is released.

With economy at stake, bureaucrats may streamline their approval processes, and with government funding businesses may ramp up vaccine production capacity. Or maybe not...
 
The following users thanked this post: SilverSolder

Offline SilverSolder

  • Super Contributor
  • ***
  • Posts: 2500
  • Country: 00
Re: Covid 19 Vaccine
« Reply #5 on: March 17, 2020, 10:54:05 pm »

Is it worth getting a regular flu shot?  - is it possible to get ill with both regular flu and Covid 19 at the same time?
 

Offline vad

  • Regular Contributor
  • *
  • Posts: 63
  • Country: us
Re: Covid 19 Vaccine
« Reply #6 on: March 18, 2020, 01:04:19 am »

Is it worth getting a regular flu shot?  - is it possible to get ill with both regular flu and Covid 19 at the same time?
Yes. Flu season is not over in the U.S., and tens of thousands die from it each year. If you are lucky enough you can get both at the same time.
 

Offline DrG

  • Frequent Contributor
  • **
  • Posts: 328
  • Country: us
Re: Covid 19 Vaccine
« Reply #7 on: March 18, 2020, 03:38:22 am »
Chief scientist on Trump’s task force said it will take 12-18 months. My hope, they will find a way to cut corners, and maybe we will see “deployable” vaccine by fall. They are already doing that, by going straight to phase 1 clinical trials, bypassing animal testing.

So, not to be too picky, the test compound, mRNA-1273, has shown efficacy (or at least "promise") in animal models. What they might have skipped is the basic animal rule requiring toxicity testing, typically 28-day and GLP in at least two animal species.

The clinical trial is for healthy normal volunteers - a simple dose-effect - Phase 1 safety. The effort can progress to Phase 2 (testing in a few folks with Covid-19) if that goes well.

It is probably the case that the push will have many candidates (already) in testing in different countries....and like you, I hope something is a hit, and soon.

https://www.nih.gov/news-events/news-releases/nih-clinical-trial-investigational-vaccine-covid-19-begins
https://clinicaltrials.gov/ct2/show/NCT04283461?term=mrna-1273&draw=2&rank=1
- Invest in science - it pays big dividends. -
 

Offline SilverSolder

  • Super Contributor
  • ***
  • Posts: 2500
  • Country: 00
Re: Covid 19 Vaccine
« Reply #8 on: March 19, 2020, 11:06:56 pm »

I went and got a flu shot today.  Apparently these things are about 50% effective in preventing getting the type(s) of flu they target.  Given that we really, really don't want to have both Covid-19 and regular flu at the same time, this seems like a sensible risk reduction strategy.
 

Offline mzzj

  • Frequent Contributor
  • **
  • Posts: 959
  • Country: fi
Re: Covid 19 Vaccine
« Reply #9 on: March 19, 2020, 11:18:58 pm »
Chief scientist on Trump’s task force said it will take 12-18 months. My hope, they will find a way to cut corners, and maybe we will see “deployable” vaccine by fall. They are already doing that, by going straight to phase 1 clinical trials, bypassing animal testing.
Umbrella corporation anyone?  >:D
 

Offline DrG

  • Frequent Contributor
  • **
  • Posts: 328
  • Country: us
Re: Covid 19 Vaccine
« Reply #10 on: March 19, 2020, 11:19:25 pm »

I went and got a flu shot today.  Apparently these things are about 50% effective in preventing getting the type(s) of flu they target.  Given that we really, really don't want to have both Covid-19 and regular flu at the same time, this seems like a sensible risk reduction strategy.

I agree. Are you in the US? Did you get the quadrivalent or old fart booster (high dose trivalent) or ?
- Invest in science - it pays big dividends. -
 

Offline SilverSolder

  • Super Contributor
  • ***
  • Posts: 2500
  • Country: 00
Re: Covid 19 Vaccine
« Reply #11 on: March 19, 2020, 11:52:50 pm »

I went and got a flu shot today.  Apparently these things are about 50% effective in preventing getting the type(s) of flu they target.  Given that we really, really don't want to have both Covid-19 and regular flu at the same time, this seems like a sensible risk reduction strategy.

I agree. Are you in the US? Did you get the quadrivalent or old fart booster (high dose trivalent) or ?

Yes, east coast.  - LOL I didn't know there were different ones.   This is the first one I've had in a decade, so it is probably not a booster...
 

Offline DrG

  • Frequent Contributor
  • **
  • Posts: 328
  • Country: us
Re: Covid 19 Vaccine
« Reply #12 on: March 20, 2020, 12:20:17 am »

I went and got a flu shot today.  Apparently these things are about 50% effective in preventing getting the type(s) of flu they target.  Given that we really, really don't want to have both Covid-19 and regular flu at the same time, this seems like a sensible risk reduction strategy.

I agree. Are you in the US? Did you get the quadrivalent or old fart booster (high dose trivalent) or ?

Yes, east coast.  - LOL I didn't know there were different ones.   This is the first one I've had in a decade, so it is probably not a booster...

Yeah, there are. The quadrivalent protects against four strains. The high dose (old fart booster) is trivalent (protecting against three strains) but 4X the antigen as compared to normal trivalent. It was offered this season for old farts with the idea that their immune systems benefist from the increase and there is some evidence to suggest that see https://www.cdc.gov/flu/prevent/qa_fluzone.htm

I asked because I had to make a case for the quadrivalent and they gave me what I asked for (although I had to put in writing that I specifically requested it). I just reasoned that I would rather be protected against for strains and, I would like to believe, that my immune system is fine. My guess is that the quadrivalent 4X will be available next season.
- Invest in science - it pays big dividends. -
 

Offline SilverSolder

  • Super Contributor
  • ***
  • Posts: 2500
  • Country: 00
Re: Covid 19 Vaccine
« Reply #13 on: March 20, 2020, 12:25:19 am »

I went and got a flu shot today.  Apparently these things are about 50% effective in preventing getting the type(s) of flu they target.  Given that we really, really don't want to have both Covid-19 and regular flu at the same time, this seems like a sensible risk reduction strategy.

I agree. Are you in the US? Did you get the quadrivalent or old fart booster (high dose trivalent) or ?

Yes, east coast.  - LOL I didn't know there were different ones.   This is the first one I've had in a decade, so it is probably not a booster...

Yeah, there are. The quadrivalent protects against four strains. The high dose (old fart booster) is trivalent (protecting against three strains) but 4X the antigen as compared to normal trivalent. It was offered this season for old farts with the idea that their immune systems benefist from the increase and there is some evidence to suggest that see https://www.cdc.gov/flu/prevent/qa_fluzone.htm

I asked because I had to make a case for the quadrivalent and they gave me what I asked for (although I had to put in writing that I specifically requested it). I just reasoned that I would rather be protected against for strains and, I would like to believe, that my immune system is fine. My guess is that the quadrivalent 4X will be available next season.

Interesting, so at what age to they switch from prescribing one over the other?  - or do they take general health levels into account?

 

Offline DrG

  • Frequent Contributor
  • **
  • Posts: 328
  • Country: us
Re: Covid 19 Vaccine
« Reply #14 on: March 20, 2020, 12:28:36 am »

I went and got a flu shot today.  Apparently these things are about 50% effective in preventing getting the type(s) of flu they target.  Given that we really, really don't want to have both Covid-19 and regular flu at the same time, this seems like a sensible risk reduction strategy.

I agree. Are you in the US? Did you get the quadrivalent or old fart booster (high dose trivalent) or ?

Yes, east coast.  - LOL I didn't know there were different ones.   This is the first one I've had in a decade, so it is probably not a booster...

Yeah, there are. The quadrivalent protects against four strains. The high dose (old fart booster) is trivalent (protecting against three strains) but 4X the antigen as compared to normal trivalent. It was offered this season for old farts with the idea that their immune systems benefist from the increase and there is some evidence to suggest that see https://www.cdc.gov/flu/prevent/qa_fluzone.htm

I asked because I had to make a case for the quadrivalent and they gave me what I asked for (although I had to put in writing that I specifically requested it). I just reasoned that I would rather be protected against for strains and, I would like to believe, that my immune system is fine. My guess is that the quadrivalent 4X will be available next season.

Interesting, so at what age to they switch from prescribing one over the other?  - or do they take general health levels into account?

I believe that they use the universal 65 metric as constituting old fart class  :).

That you are asking suggests that they probably gave you trivalent 1X and that you were not eligible for 4 X....but I could be wrong.
- Invest in science - it pays big dividends. -
 

Offline SilverSolder

  • Super Contributor
  • ***
  • Posts: 2500
  • Country: 00
Re: Covid 19 Vaccine
« Reply #15 on: March 20, 2020, 12:51:57 am »

I went and got a flu shot today.  Apparently these things are about 50% effective in preventing getting the type(s) of flu they target.  Given that we really, really don't want to have both Covid-19 and regular flu at the same time, this seems like a sensible risk reduction strategy.

I agree. Are you in the US? Did you get the quadrivalent or old fart booster (high dose trivalent) or ?

Yes, east coast.  - LOL I didn't know there were different ones.   This is the first one I've had in a decade, so it is probably not a booster...

Yeah, there are. The quadrivalent protects against four strains. The high dose (old fart booster) is trivalent (protecting against three strains) but 4X the antigen as compared to normal trivalent. It was offered this season for old farts with the idea that their immune systems benefist from the increase and there is some evidence to suggest that see https://www.cdc.gov/flu/prevent/qa_fluzone.htm

I asked because I had to make a case for the quadrivalent and they gave me what I asked for (although I had to put in writing that I specifically requested it). I just reasoned that I would rather be protected against for strains and, I would like to believe, that my immune system is fine. My guess is that the quadrivalent 4X will be available next season.

Interesting, so at what age to they switch from prescribing one over the other?  - or do they take general health levels into account?

I believe that they use the universal 65 metric as constituting old fart class  :).

That you are asking suggests that they probably gave you trivalent 1X and that you were not eligible for 4 X....but I could be wrong.

It wasn't even discussed, it was just called a "flu shot"...  I'm still (rapidly) approaching 60 so perhaps they defaulted to 4x.
 

Offline jxjbsd

  • Regular Contributor
  • *
  • Posts: 84
  • Country: cn
  • 喜欢电子技术的网络工程师
Re: Covid 19 Vaccine
« Reply #16 on: March 21, 2020, 11:40:43 am »
China's new crown vaccine has been injected into the human body for the first batch of experiments 108 volunteers
https://tech.sina.com.cn/roll/2020-03-21/doc-iimxyqwa2231078.shtml
Analog instruments can tell us what they know, digital instruments can tell us what they guess.
 
The following users thanked this post: SilverSolder

Offline SilverSolder

  • Super Contributor
  • ***
  • Posts: 2500
  • Country: 00
Re: Covid 19 Vaccine
« Reply #17 on: March 21, 2020, 06:53:54 pm »
I calculated the number of known infections on March 20 as a percentage of the country's population.  Listed below, down to 0.001%


PctInfected   Country
------------      --------
0.449753%   San Marino
0.125156%   Vatican City
0.112282%   Iceland
0.100267%   Dominican Republic
0.096721%   Andorra
0.095486%   Liechtenstein
0.078841%   Luxembourg
0.078052%   Italy
0.065405%   Switzerland
0.052921%   Spain
0.036888%   Norway
0.030014%   Austria
0.028721%   Monaco
0.024426%   Belgium
0.023870%   Germany
0.023583%   Iran
0.023168%   Denmark
0.021304%   Estonia
0.019309%   Bahrain
0.019006%   France
0.017631%   Brunei
0.017212%   Netherlands
0.017108%   Qatar
0.016993%   South Korea
0.016284%   Slovenia
0.015861%   Sweden
0.013878%   Ireland
0.012967%   Malta
0.009925%   Portugal
0.008563%   Cyprus
0.008453%   Czech Rep
0.008141%   Finland
0.008121%   Guam
0.007684%   Israel
0.007170%   Seychelles
0.006750%   Singapore
0.006503%   Latvia
0.006040%   UK
0.006001%   US
0.005797%   China
0.005410%   Armenia
0.004741%   Panama
0.004616%   Greece
0.004163%   Australia
0.004121%   Croatia
0.003659%   North Macedonia
0.003615%   Malaysia
0.003597%   Kuwait
0.003566%   Greenland
0.003469%   Maldives
0.003126%   Uruguay
0.002863%   Canada
0.002726%   Bosnia and Herzegovina
0.002593%   Lebanon
0.002511%   Slovakia
0.002470%   Lithuania
0.002461%   Moldova
0.002445%   Albania
0.002441%   Ecuador
0.002271%   Chile
0.002250%   Montenegro
0.002234%   Costa Rica
0.002140%   Serbia
0.002090%   Barbados
0.002029%   Bulgaria
0.001916%   Guyana
0.001587%   Romania
0.001416%   United Arab Emirates
0.001262%   Georgia
0.001144%   Poland
0.001119%   St Lucia
0.001115%   Oman
0.001106%   Mauritius
0.001054%   Hungary
0.001046%   New Zealand
0.001038%   The Bahamas
0.001037%   Antigua and Barbuda
0.001005%   Saudi Arabia
 
The following users thanked this post: TerminalJack505

Offline SiliconWizard

  • Super Contributor
  • ***
  • Posts: 5447
  • Country: fr
Re: Covid 19 Vaccine
« Reply #18 on: March 21, 2020, 07:01:43 pm »
The Iceland figure looks odd - as you don't expect a whole lot of traveling to and from there - although probably just explained by the fact this is a very small population (~360k), so obviously any case will contribute a lot more to the percentage.


 

Offline SilverSolder

  • Super Contributor
  • ***
  • Posts: 2500
  • Country: 00
Re: Covid 19 Vaccine
« Reply #19 on: March 21, 2020, 07:07:22 pm »
The Iceland figure looks odd - as you don't expect a whole lot of traveling to and from there - although probably just explained by the fact this is a very small population (~360k), so obviously any case will contribute a lot more to the percentage.

Iceland has a lot of tourism, and relatively few tourist destinations...   and a lot of people working in the industry.  People (including me!) use Iceland as a stop-over on the way between America and Europe.  I can totally see how this could happen.

The other factor is - how much is each country actually testing?  They will "look good" if they don't test as much as the best.
 


Share me

Digg  Facebook  SlashDot  Delicious  Technorati  Twitter  Google  Yahoo
Smf