You MUST have holes in the pads in your artwork to act as centre-marks.
If you forget, use a sharp pointy thing to make centre marks.,
These holes should be smaller than the actual drill size to avoid a gap between the hole and the pad due to over-etching , which makes soldering harder. 20 mil (0.02") is a good size for all drill diameters.
Drills should be carbide, as fibreglass eats HSS drills.
Make sure your drilling area is well lit so you can clearly see where the drill is going. Dust extraction or blowing helps a lot.