Big topic. By "chassis" I assume you mean raw drivers? There are plenty of sources for good raw drivers, but as with any kind of engineering, what you choose is more dependent on your goals than a simple good / better / best system.
Generally, small drivers have wider dispersion than large drivers. Large drivers move more air and are thus more suited to lower frequencies. Using one driver means a compromise of extension, directionality, and power-handling, while using multiple drivers means compromising phase coherency, cost, and complexity. You'll have to pick between efficiency and bandwidth as well. PA drivers are highly efficient, but require large cones and huge enclosures. Home audio drivers tend to work better in smaller enclosures, but require a lot of power. At one end of that, you have horns and transmission lines -- and at the other, undersized sealed enclosures with tons of power and heavy-handed signal conditioning.
The nice thing is, there are tools available now that were only available to high-end manufacturers 20 years ago. Software like WinISD, HornResp, PCD, and any number of RTA packages; along with hardware like DATS, measurement mics, and clean USB audio interfaces. Not to mention CNC routers.
There are probably better forums to discuss this sort of thing than here. It's a rather involved hobby and accordingly has its own ecosystem, but there's probably some spill-over between the two. Watch out for the cork-sniffing audiophiles though.