Hazardous substances aren't really a concern for something which goes up and stays up.
They do come down, but mostly as lots of very small well cooked pieces, and with 78% of the planet being water, there is little chance of them landing on land, and even less of them landing on habitable land. Of course most of the time they are controlled deorbits over the Pacific, but those that have sudden failures in either attitude control, power control or housekeeping tend to be those that do the dice roll of where they will impact.