Dellaminating? What a quality crap, never seen this, ever!
A 43" monitor will be like looking at a giant poster from 10".
I bought a HDR 165Hz QHD 27" Lenovo g27q-20 in 2020 ($299), definitely getting into the "too large" area, I often struggle to find the mouse cursor, but the higher DPI is great, specially when splitting windows, but yeah, just at the limit of the visual field.
My advice is to get QHD under 32", 4K will be too much DPI, and Windows scaling is crap, avoid using it at all costs.
I know because I installed a FHD panel into my ex laptop, when she was doing the engineering 10yr ago, 1366x768 was a no-no for CAD and 3D design.
Things were extremely small, 7pt text, but no problem, let's enable 125 (Or 150%) scaling!
Now everything looked like I had breathed all over the screen!

Now this this is the 27: