General > General Technical Chat
Vaccine
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tszaboo:

--- Quote from: Circlotron on March 17, 2021, 11:40:43 pm ---I wonder what would happen if you got the first dose of one brand of vaccine and the second does of a different brand? Would it still work? Would it cause any harm?

--- End quote ---
We have no idea. Basically the current vaccination strategy is this way, because they tested it and it worked. And then we have stupid results, like this:
https://www.openaccessgovernment.org/astrazeneca-vaccine-2/98616/
where half dose works better, they could give it to twice as many people, but it's not tested.
gnuarm:

--- Quote from: TimFox on March 16, 2021, 04:17:28 pm ---Going forward, I hope that we can make progress on anti-viral medication, since vaccines can take a long time when a new virus appears.

--- End quote ---

Going forward I hope we can make progress in people treating deadly diseases like they are deadly diseases and not talking about them as "fake" or whining about not being able to get a haircut or claiming they will simply "vanish".
gnuarm:

--- Quote from: richard.cs on March 16, 2021, 05:44:22 pm ---
--- Quote from: langwadt on March 16, 2021, 05:13:12 pm ---AstraZeneca is now on hold in many countries because some receivers have had unsual cases of blood clots some of them dying

afaiu if you had it and get unusual bruising you should see a doctor

--- End quote ---

With 37 clotting events across the 17 million doses given, I would not be in the least worried about getting the AstraZenica vaccine. In fact I find it surprising that so few have been reported, given that you'd expect something like 1/1000 people to experience a clotting event in a given year. If clots within a week of the vaccine were reported you'd expect to see 17e6/(1e3*52) =~ 300.

--- End quote ---

But you need to add to those 37 cases the number who were involved in a fatal auto accident on their way to the vaccination site.  In the US each day 1 in about 3.5 million die in auto accidents.  That would be roughly 2.5 deaths in 17 million, so the blood clots are about 10 times worse than auto risk.  I wonder how it compares to deaths due to falling down stairs or slipping in the bathtub.  Those numbers are pretty scary too.

I'm wondering how long it will be before there is a mass shooting at a vaccination site.  Just when you thought you were safe...
gnuarm:

--- Quote from: NANDBlog on March 16, 2021, 06:03:55 pm ---Come on. If you keep it serious, and talk about covid and vaccines, they will close this thread. Mods said several times it is not thematically fitting to an engineering forum.

--- End quote ---

Ok, being retired this virus has kept me at home nearly all the time.  That has allowed me to do a lot more work on electronics and FPGAs.  In fact, that is why I found this group.  I mainly posted in newsgroups before, but this group is MUCH betterer. 

A nice, supportive and reasonable bunch.  :-)
gnuarm:

--- Quote from: Zero999 on March 16, 2021, 08:02:22 pm ---
--- Quote from: TimFox on March 16, 2021, 07:44:59 pm ---The best strategy for a new pathogen is to become less lethal and more infectious, thus increasing their numbers without killing off their hosts.

--- End quote ---
Unfortunately the less lethal part doesn't apply to pathogens which spread in a/presymptomatic people, or via a third party. For example, HIV has a 100% mortality rate, without treatment and spreads rapidly in healthy people, so it has no incentive to become less deadly. The same is true with SARS-Cov 2, which whilst fortunately is several orders of magnitude less deadly, also spreads in healthy people. Unfortunately there's mounting evidence to suggest the B1525 variant discovered in the UK, is not only more transmissible, but more deadly, than the original one. A pattern which seems to be repeated in other new variants.

I know it's only wackypedia (I'm lazy) so check the references.
https://en.wikipedia.org/wiki/Variants_of_SARS-CoV-2#Overview_table

--- End quote ---

If you think about the mechanics for a moment, you will realize most increases in transmissibility will also make a given infection more serious or lethal.  The most likely change that improves transmissibility is to more readily invade a cell or reproduce in larger numbers or faster so that lower initial numbers of viruses are more likely to create an infection.  They will also make the disease more serious and deadly.  So, no surprise.
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