Author Topic: Vision problems and cataract surgery  (Read 3280 times)

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Offline cvancTopic starter

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Vision problems and cataract surgery
« on: November 04, 2018, 02:13:52 pm »
Hi all-

If you ask me I'm too young for this!  Nonetheless I'm getting cataracts removed soon.

I wonder who here has BTDT and how it has (hopefully) improved your eyesight in general and specifically the ability to work up close and personal with PC boards etc.

I think I've found a good doctor and we've discussed getting a pair of higher grade implants.  My main symptom is not softness, it's double vision, and it has really been slowing my bench work down.

Anyone been through this?  Thanks.
 

Offline Tom45

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Re: Vision problems and cataract surgery
« Reply #1 on: November 04, 2018, 03:39:27 pm »
I had both eyes done a few years ago. My problem was a lack of sharpness. Vision was getting blurry so I went in for an eye exam and new lenses. But after the exam he said my corrective lenses were already about as good as I could get and the blurriness was due to cataracts.

He recommended an outfit in the nearest large city that specialized in cataract and Lasik surgery. All went well. They did my left eye first and then a few days later my right eye. Had to wait about a month before getting new prescription for glasses that matched my post surgery vision.

This place had the procedure set up with assembly line precision. The entire process took a little over two hours. Most of that time was a series of eye drops to do various things with waits between each one. The actual surgery takes just a few minutes.

The results:

1) sharper vision. The blurred vision was gone.

2) With cataracts looking into lights is like driving a car towards a sunset with a dirty windshield. One of the preop tests measured that and it was obvious to me what the test was showing, and that my left eye was quite a bit worse.

3) Cataracts have a yellow tint to them. The day after each eye was done, I had an eye exam just to make sure everything was OK. After the first when my left eye had been done, the eye doctor said he wanted to show me something. The wall in the exam room was a dark violet color. He had me look at it with only my left eye. It was a dark violet. Then with only my right (not done yet) eye and it was gray! Was I surprised. I repeated that comparison that evening looking at a spectacular sunset. Spectacular with either eye, but with the left eye the sunset had blues that were missing with my right eye.

Tom

 

Offline Benta

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Re: Vision problems and cataract surgery
« Reply #2 on: November 04, 2018, 06:30:59 pm »
BTDT, problem was milkyness in my vision and really bad night vision. Got a plastic lens implanted, which gave me a whole new experience.
What you need to know is, that plastic lenses have a fixed focal length. I'm short-sighted from birth, so I need long-distance glasses for driving and everyday use, special glasses for computer screen vision, and no glasses for close up vision (like the boards you mention).
But never mind how your focus is, you'll most probably need at least two pairs of glasses.
It's bit of bother, but you'll get used to it and enjoy your new sharp view of the world.

 

Offline cdev

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Re: Vision problems and cataract surgery
« Reply #3 on: November 04, 2018, 08:36:24 pm »
Have you tried (commercial, not home-made) carnosine eye drops?
"What the large print giveth, the small print taketh away."
 

Offline rhb

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Re: Vision problems and cataract surgery
« Reply #4 on: November 05, 2018, 02:25:12 am »
I was a high myope from birth.  -11 to -12 lenses at 20 something.  I've had 6 eye surgeries.  Two vitrectomies for detached retinas.  One due to a blow to the eye with my wrist while adjusting the clutch on my pickup.  The other spontaneous.  Both retinal guys did a good job.

Unfortunately, cataracts appear to be an inevitable consequence of having the inside of your eyeball removed and it then filling with liquid.  The first cataract surgeon (primarily a retinal specialist) did a fine job on my right eye.  The surgeon who did my left eye botched it badly.  Lots of damage to the lens capsule, but worse than that, he didn't put the lens in the capsule.  So it was flopping about in my eye and causing very high pressure.  I was able to get it fixed by a surgeon at Baylor in Houston, but naturally he could not fix the damage to the capsule. So I then had to have a hole made in the capsule with a YAG laser.

End result is the left eye is usable for ordinary tasks getting around the house, etc, but the vision is poor enough that I really don't have good depth perception.

It's *really* worth looking for someone who only does cataract surgery.

The good news is I can still see which would not have been the case 100 years ago.  The bad news is I also have glaucoma.  So at 65 I'm in a race between dying and going blind.  I'm hoping dying comes first, but Dad lived to 91 and Mother almost to 96.  So I rather fear going blind will win :-(
 
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Offline Nusa

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Re: Vision problems and cataract surgery
« Reply #5 on: November 05, 2018, 03:03:47 am »
I haven't, but my father had cataract surgery about 20 years ago. His cataracts were bad enough in both eyes that he was blind in direct sunlight....a real danger when driving. He was originally very near-sighted and was also old enough to have age-related near-focus issues, so he elected to get lens designed for good distance vision. He needs glasses now to do close-up work. It's worked out well in his case. He's still going at 87, and while he has some health problems, his eyes are working fine.
 

Offline cdev

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Re: Vision problems and cataract surgery
« Reply #6 on: November 05, 2018, 03:23:47 am »
I made a long post earlier about how I make my own eye drops which seem to help my eyes, using a substance called l-carnosine. Commercial eye drops exist which are useful for people as an alternative to surgery. There are tons of things that may be protective to the eyes or reduce the rate of various age related insults to the eyes and nerves generally, and they are documented on PubMed to various degrees. But I shouldnt be the one advocating them, people should look at the big picture and learn how to use Pubmed.
"What the large print giveth, the small print taketh away."
 

Offline basinstreetdesign

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Re: Vision problems and cataract surgery
« Reply #7 on: November 05, 2018, 04:44:44 am »
BTDT, problem was milkyness in my vision and really bad night vision. Got a plastic lens implanted, which gave me a whole new experience.
What you need to know is, that plastic lenses have a fixed focal length. I'm short-sighted from birth, so I need long-distance glasses for driving and everyday use, special glasses for computer screen vision, and no glasses for close up vision (like the boards you mention).
But never mind how your focus is, you'll most probably need at least two pairs of glasses.
It's bit of bother, but you'll get used to it and enjoy your new sharp view of the world.

This describes me almost perfectly.  My optometrist is starting to make noises about cataract surgery and how it will eliminate my need for glasses altogether.
STAND BACK!  I'm going to try SCIENCE!
 

Offline edpalmer42

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Re: Vision problems and cataract surgery
« Reply #8 on: November 05, 2018, 05:01:49 am »
BTDT, problem was milkyness in my vision and really bad night vision. Got a plastic lens implanted, which gave me a whole new experience.
What you need to know is, that plastic lenses have a fixed focal length. I'm short-sighted from birth, so I need long-distance glasses for driving and everyday use, special glasses for computer screen vision, and no glasses for close up vision (like the boards you mention).
But never mind how your focus is, you'll most probably need at least two pairs of glasses.
It's bit of bother, but you'll get used to it and enjoy your new sharp view of the world.

This describes me almost perfectly.  My optometrist is starting to make noises about cataract surgery and how it will eliminate my need for glasses altogether.

How does that work?  As Benta said, plastic lenses only focus at one distance so how will you see clearly at other distances?

Ed
 

Offline wilfred

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Re: Vision problems and cataract surgery
« Reply #9 on: November 05, 2018, 05:20:08 am »
I went for distance lenses so I could drive, walk around and watch TV. I wear glasses for computer and reading.

I found it a quick and straightforward experience. As others have said it is the waiting around on a trolley with a sequence of drops being put in your eyes that was the time consuming part. The actual surgery was very quick.

And if you were to ask me I also thought I was too young for cataract surgery. But there are different types apparently.

Anyone thinking about, just get it over and done with. I was a bit worried beforehand but as is typical of things I worry about, I needn't have.
 

Offline Tom45

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Re: Vision problems and cataract surgery
« Reply #10 on: November 05, 2018, 08:28:46 am »
How does that work?  As Benta said, plastic lenses only focus at one distance so how will you see clearly at other distances?
Ed

For most people that need cataract surgery, they are old enough that they can't readily focus at various distances. So they have to use multifocal glasses, or reading glasses anyway. I've been wearing tri-focal glasses for many years, so the only difference after cataract surgery is that the prescription has changed.

Tom
 

Offline rhb

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Re: Vision problems and cataract surgery
« Reply #11 on: November 05, 2018, 02:55:03 pm »
The focus for both my eyes is at about 3 ft.  That turns out to be quite convenient.  I normally don' wear glasses unless reading, etc or driving on a long trip where I need to be able to read road signs at driving speed.

So I have lots of cheap readers and a pair of distance glasses for driving.  I am going to get a pair of bifocals, but it's not been high priority.

Setting the focus for a high myope is rather hit or miss because of the difficulty measuring the length of the eye.  I've become slightly more near sighted since the surgery and have shifted from 2 diopter readers to 1.5.
 

Offline cdev

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Re: Vision problems and cataract surgery
« Reply #12 on: November 05, 2018, 03:19:53 pm »
This is a US-based study that was done on dogs with eye drops containing n-acetyl-carnosine.

Dogs seem to be particularly susceptible to cataracts.

https://www.ncbi.nlm.nih.gov/pubmed/16939459

1. Vet Ophthalmol. 2006 Sep-Oct;9(5):311-6.

The effect of a topical antioxidant formulation including N-acetyl carnosine on
canine cataract: a preliminary study.

Williams DL(1), Munday P.

Author information:

(1)Department of Veterinary Medicine, University of Cambridge, Madingley Road,
Cambridge, CB3 OES, England, UK. doctordlwilliams@aol.com

OBJECTIVE: To determine the efficacy of a topical antioxidant formulation
including N-acetyl carnosine in the treatment of canine cataract in a preliminary
nonplacebo, controlled, unmasked study.

ANIMALS STUDIED: Thirty dogs of varying breeds and ages with a spectrum of lens
opacities ranging from nuclear sclerosis to total mature cataract.

METHODS: Dogs were treated three times daily with topical 2% N-acetyl carnosine
in a buffered vehicle containing the antioxidants glutathione, cysteine
ascorbate, L-taurine and riboflavin (Ocluvet, Practivet, Phoenix, AZ, USA). Dogs
were examined prior to treatment and at 2, 4 and 8 weeks during treatment, by
direct and indirect ophthalmoscopy and slit-lamp biomicroscopy after
pharmacologic pupil dilation. Photographic documentation of lens opacity was
achieved by retroillumination photography, with three photographs taken at each
examination time-point. A lens opacification index (LOI), determined by
integration of the grayscale level of each pixel across the image, was evaluated
by computerized image analysis of digitized images. Alteration in mean LOI was
determined for each animal, having normalized the initial LOI.

RESULTS: Fifty-eight eyes of 30 dogs were evaluated, 22 with mature cataract, 13
with immature cataract, 9 with cataract associated with other intraocular disease
such as uveitis and 14 with nuclear sclerosis alone. One dog was unilaterally
anophthalmic after previous enucleation and one had a phthytic eye after previous
uveitis-induced glaucoma. Image analysis showed a reduction in mean LOI in all
cataract groups (mean resolution in opacity of 2.3 +/- 0.33% for all cataracts),
although this was only statistically significant in those eyes with immature
cataract (mean resolution of opacity 4.5 +/- 0.33%) or nuclear sclerosis (mean
decrease in opacity 5 +/- 0.37%). Reduction in lens opacity was seen in eyes with
mature cataract (0.5 +/- 0.4%) and in miscellaneous cataract associated with
intraocular inflammation (1.3 +/- 0.4%), but these changes were not statistically
significant. Owner evaluation of visual capability, however, suggested
improvement in vision in 80% of cases by the end of the study.

CONCLUSIONS: This study demonstrates some marginal reduction in lens
opacification in a substantial number of cases of canine cataract with the use of
a topical nutritional antioxidant formulation including N-acetyl carnosine. Lens
opacification was improved with treatment in eyes with immature cataract or
nuclear sclerosis while in eyes with mature cataract or cataract with associated
intraocular inflammatory pathology less reduction was seen.

DOI: 10.1111/j.1463-5224.2006.00492.x
PMID: 16939459  [Indexed for MEDLINE]
« Last Edit: November 05, 2018, 03:27:31 pm by cdev »
"What the large print giveth, the small print taketh away."
 

Offline Benta

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Re: Vision problems and cataract surgery
« Reply #13 on: November 05, 2018, 04:48:05 pm »
BTDT, problem was milkyness in my vision and really bad night vision. Got a plastic lens implanted, which gave me a whole new experience.
What you need to know is, that plastic lenses have a fixed focal length. I'm short-sighted from birth, so I need long-distance glasses for driving and everyday use, special glasses for computer screen vision, and no glasses for close up vision (like the boards you mention).
But never mind how your focus is, you'll most probably need at least two pairs of glasses.
It's bit of bother, but you'll get used to it and enjoy your new sharp view of the world.

This describes me almost perfectly.  My optometrist is starting to make noises about cataract surgery and how it will eliminate my need for glasses altogether.

How does that work?  As Benta said, plastic lenses only focus at one distance so how will you see clearly at other distances?

Ed

It doesn't work quite that way. The eye focus length from around 6 ft to infinity is appr. the same, and if you have both eyes done, you can go for this. If you so, you'll need glasses for computer use (2...4 ft.) and glasses for reading (1...2 ft.).
If you're only getting one eye done, it makes sense to align the two eyes to appr. the same dioptries.

 

Offline rhb

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Re: Vision problems and cataract surgery
« Reply #14 on: November 05, 2018, 07:31:37 pm »
They now sell deformable implants.  As my eyesight is very dear to me, I went with the hard acrylic lens which have the longest track record.  But they market the deformable lenses a treatment for presbyopia,
 

Offline VK3DRB

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Re: Vision problems and cataract surgery
« Reply #15 on: November 09, 2018, 11:18:36 am »
I also had cataracts at a youngish age, which got progressively worse over time. My previous role was an electronics engineer in the medical industry working on developing ophthalmic products, and fortunately I was working on a project with the Director of Ophthalmology at the Victorian Eye and Ear Hospital. He is the best in the field. I got a great deal from him and got them removed. My left eye now has a lens put in it with a focal length of infinity. The right one has a focal length at arm's distance. The result is I do not nee glasses except for working closely on electronics.

With different focal lengths, the brain switches from eye to eye automatically after a while (takes up to 6 months for this to occur). I can see clearly close or far away. Fantastic and highly recommended.

After cataracts are removed the weirdest sensation is everything so bright and white is incredibly white!
 

Offline cdev

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Re: Vision problems and cataract surgery
« Reply #16 on: November 09, 2018, 01:50:48 pm »
n-acetyl-carnosine eye drops do appear to reverse the loss of opacity from cataract to some extent. The change is lasting.

They are currently available OTC for both people (expensive) and pets (cheap)
"What the large print giveth, the small print taketh away."
 

Offline lordvader88

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Re: Vision problems and cataract surgery
« Reply #17 on: November 10, 2018, 04:18:52 am »
How does the cataract surgeries work ? is there pain ? how do they stop your eye from moving ?

scary sounding stuff
 

Offline Tom45

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Re: Vision problems and cataract surgery
« Reply #18 on: November 10, 2018, 06:18:03 am »
How does the cataract surgeries work ? is there pain ? how do they stop your eye from moving ?

scary sounding stuff

They give you a series of eye drops over roughly an hour. I don't know what all the drops are for, but one result is that the eye muscles are paralyzed. You just can't move your eye. Before the surgery I was also sceptical that I'd be able to keep my eye still.

The actual surgery consists of making a tiny incision to remove the original lens. And then insert the new lens. This takes just a minute or two. Strange to see this happening. A blurry light show for a short while and then it's over. There is no pain from the surgery.

Definitely scary sounding. Not so bad in actuality.
 

Offline digsys

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Re: Vision problems and cataract surgery
« Reply #19 on: November 10, 2018, 08:53:45 am »
I had the same procedure on my left eye ~5 months ago. Eye drops to numb it, a patch over the right eye .. weird blurry lights :-)
There was bruising for several days, but no pain at all that I recall. No driving for a few days, as the eye must stay covered for ~2 weeks, and eyedrops
twice a day. Not that bad at all .. Results ....
I went from ~ 20:38ish to 20:12ish. A white object with my left eye was IN FACT YELLOW with my right !! All greens and blues were INTENSELY more vivid !
I kept stopping at parks and literally counting leaves on the trees !! It was bloody awesome ! Stoopid body has now adjusted, and all is "normal" now :-)
Even so, I can see street signs at night, with oncoming headlights waaay in the distance. Felt like I almost had X-Ray vision :-)
WELL worth it !! I was thinking of doing my right eye with either a dual lens of a fixed closer focus one, like one reply here. Still mulling it over.
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Offline VK3DRB

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Re: Vision problems and cataract surgery
« Reply #20 on: November 10, 2018, 11:20:21 am »
How does the cataract surgeries work ? is there pain ? how do they stop your eye from moving ?

scary sounding stuff

They work wonders. Pain like sand in the eye for a few hours - best to sleep it off. Next morning, all is well and you will smile when the eye patch is removed. You have to put in eye drops a few times a day for a month.

You have the operation whilst awake - somewhat drugged. I never taken illicit drugs in my life and only been drunk on alcohol only once. But I can understand what getting high is like, after being partially anaesthetised for an hour or so. I was telling the ophthalmologist about the processor in the XBOX 360 whilst having the operation. I could see the needle go into the eyeball and the lens unwrapping though the cannula.

It was cool! Nothing scary. The risk is very low if you go to a good ophthalmologist. Just do it!

 

Offline vtwin@cox.net

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Re: Vision problems and cataract surgery
« Reply #21 on: November 10, 2018, 01:44:43 pm »
Ophthalmologist told me I had cataracts two years ago (at 52). Other than things being blurry (which, since I have astigmatism, I'm used to anyway) I hadn't noticed them (was surprised when he told me).

I have to find a doctor who will put me out while they do the procedure, even if it means I have to pay out of pocket for the anesthesiologist. There is no way I could be awake for it, even drugged.

I know a few people who go for injections in their eyes for macular degeneration. Beats going blind, I imagine, but I'd hate to think about the amount of drugs I would need for them to give me to allow them to do that to me.
A hollow voice says 'PLUGH'.
 

Offline cdev

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Re: Vision problems and cataract surgery
« Reply #22 on: November 14, 2018, 11:10:09 pm »
When I posted the other day I was fairly sure that somewhere in my stuff I had some old Russian literature about the use of carnosine (not the patented n-acetyl-carnosine) for cataracts.

One journal article is from Biokhimiya (Moscow) from 2000. I don't have a complete copy, just its abstract handy. But I am pretty sure its on the web, just a bit pressed for time now. (Edit- Link added)

The earlier Russian experience with l-carnosine eye drops is described in "MINI-REVIEW: Use of Carnosine as a Natural Anti-senescence Drug for Human Beings" by
A. M. Wang, C. Ma, Z. H. Xie, and F. Shen

PDF version: http://protein.bio.msu.ru/biokhimiya/contents/v65/pdf/bcm_0869.pdf




1
Biochemistry (Moscow), Vol. 65, No. 7, 2000, pp. 869-871. Translated from Biokhimiya, Vol. 65, No. 7, 2000,
Pp. 1022-1024.Original Russian Text Copyright © 2000 by Wang, Ma, Xie, Shen.
Biochemistry (Moscow), Vol. 7 , No. 65 , 2000 , pp. 869-871 . Translated from Biochemistry (Biokhimiya) , 2000 , issue 7
65 volumes, 1022-1024 pages. Original Russian version Copyright © 2000 by Wang (Wang) , Ma (Ma) , Xie (Xie) , Shen (Shen) .
Small comment
Carnosine as a natural anti-aging drug for human use
AM 王 ' *, C. Ma, ZH Xie
'
, and F. Shen
'
Department of Biochemistry, Department of Neurobiology, Harbin Medical University, China 2 , Zip Code 150086
Included on October 29, 1999
Email: Wangam@ems.hrbmu.edu.cn

also https://ethos.ag/cataracts-wang-chinese.pdf

Abstract: Carnosine is an endogenous free radical scavenger. Recent research shows that in addition to preventing cells from being oxidatively induced by stress damage
In addition, carnosine can prolong the life of cultured cells, activate senescent cells, inhibit amyloid peptide (A β ), malondialdehyde, hypochlorous acid
The toxic effects of salt on cells, the inhibition of glycosylation of proteins, and the cross-linking between DNA and proteins and proteins.
And maintain cell homeostasis. At the same time, carnosine can delay the decline of vision caused by aging, effectively preventing and treating aging white
Internal ailments and diseases caused by other ages. Therefore, for humans, carnosine can be used as an anti-aging drug.
Keywords: carnosine, anti-aging drugs
Carnosine is a non-enzymatic free radical scavenger and a natural antioxidant [1, 2]. It is generally distributed in organizations, especially
It is highly concentrated in muscle and brain [3, 4]. Carnosine is produced by Russian scholars Gulewitsch and Amijo
Amiradzibi discovered in 1900 [5], and other biologists such as Severin and
Boldyrev also contributed to the study of the bioavailability and medical applications of carnosine. Overall,
Although the biological properties of carnosine are not as well known as SOD, vitamins C and E, scholars around the world still resist it.
Characteristics, immunomodulator effects, and neuronal free radicals are highly protective [6-8]. Different studies have shown that muscle
Peptides can be used to treat gastric ulcers, burns, hypotension, and anti-brain ischemia/reperfusion injury [1, 9]. The purpose of this article is
This is an experimental study and medical application of carnosine as an anti-aging drug.
Free radicals and aging
Since American scholar Harman [10] pointed out that free radicals may be one of the important factors causing aging and aging diseases.
This theory has gradually been recognized by many scholars around the world.
Many findings have clearly shown that the emergence and development of aging and aging diseases are closely related to cellular damage caused by oxygen free radicals.
Related, it causes cell instability and loss of function, leading to the emergence of aging and aging diseases. Atherosclerosis,
Diseases such as diabetes [11], Alzheimer's disease [12, 13] and aging cataract [14, 15] are associated with free radical damage.
Related. Later studies on the bioavailability of different free radical scavengers and antioxidants have proven that they have a protective
The cells are protected from oxygen free radical damage and normalize cell metabolism. Some well-known antioxidants such as SOD, vitamins
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E, EGB761 and melatonin have been used in medical practice and have achieved good results. So scholars all over the world
Holding the same desire - hope to explore and develop a more effective free radical scavenger to extend life.
Evidence of carnosine anti-aging utility
The bioavailability and medical applications of carnosine have been studied extensively and intensively. In addition to being an antioxidant and free radical scavenging
In addition to the agent, carnosine also activates cell membrane enzymes, inhibits protein non-enzymatic glycosylation and modulates immunoreactivity. The nearest one
These data report that carnosine has the ability to activate senescent cells [16]. Our research in medical applications also shows that carnosine can
To delay the decline of vision caused by aging, while effectively preventing and treating aging cataracts.
In vitro experimental evidence of carnosine anti-aging utility. McFarland and Holliday [16] studied
Effect of carnosine on the growth, morphology and longevity of cultured human diploid fibroblasts. They proved through experiments that
On the Dulbec medium (DMEM), under the action of 50mm carnosine, the shape of the cultured cells is flat, scattered, and the cells
evenly distributed. And these cells grow with this same morphological characteristic throughout their entire life cycle. They found that
Under the action of carnosine, these progeny cultured cells do not exhibit aging morphological features. In this experiment, when the cell population is multiplied
When the number (PDs) is 55.3 and 55.1, that is, when signs of aging appear, the MRC-5 cells are controlled to be transferred to the muscles.
On the medium of the peptide, these cultured cells showed significant signs of activation. These cells continue to grow slowly for 274 days, and
Eventually at the PD level, this is significantly higher than the control group level.
McFrank and Hadley used MRC-5 and HFF-1 cells to detect the efficiency of carnosine for cell ligation and plating [17]
. They observed that on the Dulbec's medium, under the action of 20mm carnosine, carnosine has colony formation on young cells.
The obvious stimulating effect has a more significant effect on the aging cells of the offspring. They also found that carnosine has a significant effect on activated cells.
It stimulates the formation of more flora and has a larger colony area. Among them, the largest flora formed from a single cell is equivalent
15PDs. Through other experiments, it was found that the length of life and the increase in carnosine measurement increased in the same proportion.
McFarland and Hadley observed that under long-term effects, carnosine can promote cell bonding and survival, and long-term
Cells cultured in a medium containing carnosine are more standard than those cultured in a medium that is not injected with carnosine.
Phenotype. Use three different methods (microscopy, flow cytometry, and an ELISA target for DNA oxidative damage)
(Remarks), Kantha et al [18] used mouse embryonic fibroblasts to study L-carnosine pair in nutrient culture.
Study of cell morphology retention effects. Under the microscope, they found that under the same nutrient culture, contrast control
The cells on the medium retain the morphological characteristics of the cells on the 30 mm L-carnopeptide medium, and the cell integrity remains.
All around. By flow cytometry, the proportion of cell damage occurring in the control group was significantly higher than that given 30 mmL-carnosine.
The proportion of fibroblasts in the Burke medium. Viability of fibroblasts on 10mmL-carnosine medium
Characteristics, intermediate levels for the control group and 30 mm L-carnopeptide medium. 8-OH-dG is one of DNA oxidative damage
The main product. According to their report, after five weeks, fibroblasts in the control group showed 8-OH-dG release.
Significant (5 fold) increase in dose (p < 0.05); however, cells cultured on 30 mmL-carnosine medium did not show
This significant increase in 8-OH-dG. These results indicate that in the condition of nutrient culture, in continuous fibroblast culture
, carnosine can maintain cell morphology retention.
Fibrosis of amyloid peptide is an important feature of Alzheimer's disease (AD) [19]. Amyloid peptides are widely recognized and increased
Oxidative stress in cerebral vascular endothelial cells and smooth muscle cells, thus forming peptide accumulation in the AD phase [20], which inhibits endothelial cells
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It replicates and has a direct toxic effect on the peripheral and vascular endothelium. Amyloid peptides in the brain can cause damage to the blood-brain barrier
hurt. Scholars such as Preston et al. [7] studied carnosine pairing by invigorating rat brain vascular endothelial cells (RBE4).
The protective effect of short forms of amyloid peptides on toxic cells. Reduced mitochondrial dehydrogenase activity, lactate dehydrogenase release and
Determination of glucose consumption, they found that the rapid addition of 20mm carnosine before amyloid peptide treatment can effectively prevent 200 and
The toxic effect of 300 mg/ml amyloid peptide on cells. They pointed out that the protective mechanism of carnosine lies in its anti-glycation and anti-oxidation
Activity, during AD, both saccharification and oxidation can cause damage to neuronal nuclear endothelial cells.
Medical applications of carnosine. From our research, we have reported [21, 22] that eye drops containing 20mm carnosine have been
It is used to treat 96 patients aged 60 years with varying degrees of aging cataract, with a morbidity ranging from 2 to 21 years.
The experimental method is that after stopping all other anti-cataract drugs, the patient drops 1-2 drops of the eye drops containing carnosine to each eye.
3-4 times a day, treatment time is 3-6 months. Changes in the degree of visual recovery and changes in lens transmittance for the evaluation of carnosine treatment
Estimate the index. The results showed that for the initial aging cataract patients, carnosine showed a significant effect, the cure rate was 100%.
For patients with late-stage aging cataract, the cure rate of carnosine is 80%. For other types of cataract patients, carnosine is also the same
Shows a good therapeutic effect.
 In the observed cases, no side effects were produced. In recent years, we have used the same

The eye drops of the myopeptide content are treated in about 1000 aging cataract patients. These studies have achieved similar results (coming soon
publishing).

In addition, we use myopeptide eye drops to treat patients with varying degrees of visual impairment (no cataract) from 48 to 60 years old.

. The treatment period is 2-6 months. The experimental results show that carnosine can alleviate eye fatigue and improve vision to some extent (If you give a clearer view, you can significantly improve your vision). Patients say that carnosine can brighten and relax their eyes. also It is important to note that the medical applications of these carnosines are of statistical importance.

Therefore, carnosine is a potential drug for the prevention and treatment of aging cataracts and delaying visual aging (a sign of aging). Pharmacology of carnosine
The effect seems to be that it can be immersed in the lens [14, 23], improve the antioxidant capacity of the lens, increase the nano-, potassium-triphosphate
Adenosidase [24, 25] activity regulates metabolism and other physiological responses of the lens. According to reports, in Australia and Russia
Rose, carnosine may be proposed for skin care and wrinkle removal, for nourishing treatment in Germany. Our data also proves the muscle Peptides have anti-aging effects. All of these results can provide valuable data for the use of carnosine as an anti-aging drug.


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It really does amazing things for the eyes. A pet version is available in the US, for around $50 for a 15 ml bottle.

Or you can make it yourself fresh every couple of days using distilled water, a bit of sterile salt, a tiny bit of sodium bicarbonate (baking soda) and a very tiny bit of l-carnosine. It improves vision dramatically and the results are lasting, its not like a drug - the clarifying effect lasts, it doesn't wear off.

Unfortunately, I still have myopia, and some other eye issues. But, Ive had them for a long time. The above paper is true, it does improve vision substantially.
« Last Edit: November 15, 2018, 01:30:56 am by cdev »
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