I've worked in 'interesting' places before now, USB security is a done deal if you know what you're doing and invest the right money, it's possible to lock down a machine as soon as you plug in a different keyboard or any other non whitelisted device.
Makes it fun when 'Dave' plugs his phone in to charge.
Physical security is always worth having too, if for nothing else than to make it obvious that people shouldn't be messing about with the machines.
Concur on the 'wedged' doors, I've seen all sorts of methods and justifications for bypassing security, all of which would have caused havoc if they'd been spotted by someone in security