General > General Technical Chat
Working From Home - Impacts of Coronavirus
cdev:
--- Quote from: thinkfat on May 12, 2020, 07:10:32 pm ---I repeat: this is the wrong place.
PS:
--- Quote ---Wahedi HM1, Ahmad S2, Abbasi SW1.
https://www.ncbi.nlm.nih.gov/pubmed/32345140
--- End quote ---
Full text is here: https://www.tandfonline.com/doi/full/10.1080/07391102.2020.1762743
You must be kidding: This is not even in vitro. This is a molecular simulation study.
--- End quote ---
Can I ask you something? why are you arguing with me when I'm just suggesting we investigate this.
Why are you afraid of- having more knowledge?
Buriedcode:
--- Quote from: cdev on May 12, 2020, 07:35:23 pm ---Yes, and there are a lot of them.
--- Quote from: thinkfat on May 12, 2020, 07:10:32 pm ---I repeat: this is the wrong place.
PS:
--- Quote ---Wahedi HM1, Ahmad S2, Abbasi SW1.
https://www.ncbi.nlm.nih.gov/pubmed/32345140
--- End quote ---
Full text is here: https://www.tandfonline.com/doi/full/10.1080/07391102.2020.1762743
You must be kidding: This is not even in vitro. This is a molecular simulation study.
--- End quote ---
Can I ask you something? why are you arguing with me when I'm just suggesting we investigate this.
Why are you afraid of- having more knowledge?
--- End quote ---
I don't think it is a fear of "having more knowledge" but rather having discussion (and if shows promise, "research") squandered on poor solutions just because someone believes in a cure-all. If you were some authority that had to allocate man-hours and resources researching possible treatments, you would first follow lines of inquiry that have some evidence of efficacy, regardless of personal beliefs. They might be dead ends, but you start with what you know, eliminating them one by one until you're left with less plausible avenues. If there was ample evidence for what you're suggesting, surely others would have picked up on it? It's not like a brand new compound, it has been studied a fair bit.
You can't just "try anything and see what works" on a whim, because it would take forever. I'm sure authorities aren't resistant to the idea of certain drugs being effective just because of some dogma, or "big pharma", it is almost always because there just isn't sufficient evidence to warrant further investigation.
Also, AFAIK, we are all engineers, not doctors, and whilst perhaps there are some biochemists and specialists on the forum, I doubt any are in a position or start animal testing of a compound that has shown little promise:
https://en.wikipedia.org/wiki/Resveratrol
https://sciencebasedmedicine.org/resveratrol-of-mice-and-men/
thinkfat:
--- Quote from: cdev on May 12, 2020, 07:35:23 pm ---Can I ask you something? why are you arguing with me when I'm just suggesting we investigate this.
Why are you afraid of- having more knowledge?
--- End quote ---
I'm arguing the "we". This is not the right audience to plead your case.
Just look at the studies you're presenting. Nobody here has the knowledge to critically appraise them. This is all far, very far from any clinical application. Many of the recent papers, especially when the subject is COVID-19 are not even peer reviewed yet and if you listen to the actual experts in the field - there's a tonne of papers being published right now by who-knows, "publish or perish" is the game. This is not "more knowledge", this is just noise, "techno-babble", to my ears.
You say you're not a doctor. You most certainly are not a virologist or molecular biologist or any applicable -ist and if you think you understand what these papers are about and what they represent in the overall landscape of covid-19 research, I believe you're fooling yourself. Would you know what a 125µM dose of resveratrol represents when applied to a cell culture (I took this from the MERS paper)? Would you know that a 1µM dose is already called "extreme"? Is this a concentration that can be achieved through medication at all? How high would you have to dose it in an aerosol? How high in a "pill"? Is this even feasible, without killing the patient?
None of this will have any relevance for medical treatment for the next couple of _years_. Yes, it's "promising", from the point of view of the research team, because it promises more funding. But that's about it.
PS: The often-cited study on the effect of Hydroxychloroquine on virus replication in a cell culture mentioned 50% inhibition with a dose of 1µM. Just to put things into perspective.
Electro Detective:
--- Quote from: SiliconWizard on May 12, 2020, 02:18:43 pm ---
--- Quote from: Electro Detective on May 12, 2020, 09:47:18 am ---Don't hold your breath waiting for a vaccine :horse:
Decades later they are still working on magic cures for the common cold, re-badged flu, hay fever, winter morning sniffles,
(...)
--- End quote ---
Sorry for being naive maybe here, I certainly do not know all vaccines in existence.
But do we actually have any working vaccine to protect effectively against any coronavirus at this point?
--- End quote ---
You're far from naive mate :-+ application for 'sorry' acceptance has been declined ;D
The long :=\ and short answer is a NO, but test tube incompetents and or crooks desperate to stay in business will say YES for a colored water placebo 'trial release'
or wimp out with 'getting closer to a breakthrough..' anyway, as they have done so-o-o many times before.. which few choose to remember
to keep us hanging on, like watching a cliff hanger movie :popcorn:
or a classic DJ Youtube video with a big dollar dumpster score on the bench > will it work, easy fix,
or magic smoke, sparks n flames? :scared:
anyone with a clue about how symptoms, diseases, viri/viruses, and how the body immune system works, reacts, accepts and rejects, would know it's impossible,
and not everyone has the same physiology and tolerance to afflictions, and or drugs pumped into them to combat symptoms or ailments.
and that's aside from the shady science and pharma companies keeping the little people and gubbermint departments in the dark about ALL such matters
and or milking any situation involving the latest greatest 'hitherto unknown and UNSEEN' corona/covid badged mortality maker for all it's worth
Most drug companies originated back in the 1800s (perhaps earlier?) as street dope dealers, mickey finn muggers, and snake oil floggers
then became 'legit' with all the money and property they ripped off the hard working faith suckers over decades,
look up their 'history', that's if they haven't sent in their Wiki and Google well paid 'moderator' trolls yet, to 'censor' it up a bit, or soften the dark bits accordingly
Any landslide or diversionary comments, silly charts and cash for comment 'science' goon bully talk to sway and confuse,
won't ever change that fact that there will be NO zip nada nein etc working vaccine for corona, camry, corolla, Hi-Lux, Swine,
Mad Cow, Fat Cow, Bird Flu, Pig Flu, Bat Flu, 'pick a Country' Flu, Hollywood Flu, Stupid Flu, (enter your fav flu here), any time soon
The only current working vaccines and preventative medicine drugs are the old school boring stuff > eat well, stay healthy in body/mind and be reasonably fit,
and only indulge in pain relief poppers or booze when absolutely necessary
and hope the bastards don't poison your community's water supply or food chain (old school 'OUTBREAK')
or stick you with a 'mandatory vaccine' the administers would not dare jab themselves with
or their family, friends and cohorts,
because that suss stuff is reserved only for clean tax payer guinea pigs,
not the filthy minded rats in human form trading as.. well you can probably guess by now
--------------------------
I think I gabbed it too much again :-\ so getting set for the conspiracy deniers to pummel me once more,
= troll calling, baiting, off topic, chasing off new members, report, hassle the admin, ousted,
all that good stuff, for whatever it takes to suppress any boat rockers popping questions
I'll admit they are good at it, versatile, discrete teamwork play, extremely persistent, so credit given where due :clap:
coppice:
--- Quote from: SiliconWizard on May 12, 2020, 02:18:43 pm ---
--- Quote from: Electro Detective on May 12, 2020, 09:47:18 am ---Don't hold your breath waiting for a vaccine :horse:
Decades later they are still working on magic cures for the common cold, re-badged flu, hay fever, winter morning sniffles,
(...)
--- End quote ---
Sorry for being naive maybe here, I certainly do not know all vaccines in existence. But do we actually have any working vaccine to protect effectively against any coronavirus at this point?
--- End quote ---
Nope. They were working on a SARS vaccine when SARS was infecting people. When SARS went away they stopped work, even though a mutation of SARS was highly likely to return.
Prevention may be better than cure, but cures are where the money is. That has been the history of vaccines in general.
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