I'll have to look at the Pub/Sub stuff more closely. Back in the late 90's early 2000's I wrote hierarchical publish/subscribe servers, best effort delivery and guaranteed delivery multicasting clients and servers over TCP/IP. We later extended this with gateways and store and forward servers so that clients that were subscribed to subscriptions offering guaranteed delivery semantics could go down and/or offline and get everything they missed. Clearly you can't do this store and forward in an embedded environment, but even back then I often thought about putting the basic pub/sub at the board level.
I think that's what you are doing at the software level board to board, but maybe your using the 16Mb/s QuickStack bus to achieve this.
However, I agree with what's been said already, the QuickStack API just looks a like basic library of function calls on an RTOS, and doesn't really add much value as free electron pointed out.
The concept is great though: stack another board, copy/paste the code and change the address and it just works. That's a great achievement.
Regarding the 2.5V reference, didn't the designer read the datasheet there? in just 2 minutes reading the datasheet I saw that it needs a <100 ohm series resistor when used in unity gain configurations with load capacitance greater than 100pf. Actually having the 100nf there is good to make sure that it is dominating the added capacitance of added boards(2V5_Ref is on the left interconnect), so I think having the 100n there at the output is good, it just needs to have a low value series resistor there too, looking at the graph figure 4-4 maybe extrapolate to 82 ohms or so.