Personally I've always found programming easier than spreadsheets, ever since I learnt programming that is. Is this unusual? Writing a series of commands and defining variables always feels much more like the algebraic underlying operations than clicking around in a spreadsheet does, and whilst people are (regrettably, as it was with my case) often taught spreadsheets before encountering programming languages, they are taught the basic mechanics of what a programmed series of lines does (the whole concept of maths, and of following recipes) earlier than they encounter spreadsheets. And I struggle to believe anyone "at the coal face"* in biology thesedays wouldn't have been taught a programming language during their degree or early when starting work in the field.
As for "more work" in the likes of R or python, when you're doing one of the common data handling tasks you can always resort to the "copy it from stackoverflow" answr and modify it accordingly to specifics of your individual use case, still better than Excel. And as for collaborating with people who can't program, they can still run a programmed script you give them, and can probably do so with greater confidence than they can try to fiddle in a spreadsheet. Program code in R or Python is all there on show, trying to reverse engineer a spreadshet attempt to handle data is a much more miserable task.
*sure, in biology the older professors might not have learnt programming, but they're also not the ones who'd be handling these demon spreadsheets, they're sitting back having high concept ideas not slogging away at the data directly