I'm trying to decide which is the best way to go when it comes to circuit board design and simulation software.
It really depends how complex your boards are & how much money you will earn from your designs. Altium Designer is one of the mostly wide used professional PCB design suites. Cost is approx US$9K but you can often barter with them a bit. Consider buying a cheap package from someone else & doing a cross-grade, or using their lower end Circuit Studio package.
Learning curve of AD is quite high, but it is fairly powerful. There are other expensive packages around such as Mentor.
You mention KiCAD. It is not nearly so powerful as AD but it might do all you require & it is free. The fact that you can't have any background colour in the schematic package other than white & the only background colour in the PCB package on offer is black, just goes to show that there is much room left for improvement.
I have AD, Proteus & DipTrace. I like DipTrace the most & so it is my tool of choice.
In my opinion most of the chips these days are not easy to breadboard without soldering them onto an adapter board which is very time consuming to test a very simple circuit
This is hardly worth your time. Have your prototype boards cheaply made in China. You will have them in a week. Then send them out to a contract SMD assembler for populating.
I have used MultiSim and find I that I both love and hate it. When its not complaining for some unknown reason its worth every penny but I have spent most of my time trying to figure out why my circuit worked 5 minutes ago and now it doesn't even though I made no changes.
Remember that MultiSim seems not to like a computer going into "hibernate" or "suspend" mode. Don 't have too many other programs running & always shut your computer down & do a full restart.
Not sure what else you can use as MultiSim is one of the more powerful simulators. Your alternatives are LT Spice & its derivatives.
I hope this all helps