A clearance of 3mile is quite big, I have never seen a PCB of that size.
I also have some question marks around using guard traces around microcontroller pins, although this one has built in analog opamps.
But even so, how good are these opamps and how much noise is coupled in from the uC itself?
Guard traces are usually useful in high impedance circuits, while this IC is geared towards motor control, which is a noisy environment, but also low impedance.
I had a look at the design rules from Aisler (Because they also do assembly):
https://aisler.community/t/pcb-design-rules/41But for 4-layer PCBs they only go to 125um and you want about half of that.
TQFP's are still quite easy to solder manually. It's usually a combination of accurate positioning (Use a stereo microscope) and then use lots of flux and drag a big blob of solder over the pins.
If you go manual, then you could do some extra things. For example, maybe you can remove some pads to make room for your guard traces, and then cover them with both solder mask and silkscreen. Nobody in their right mind would give a guarantee for this, but with two layers of paint in between it probably works. You can even lift or break off some pins. Maybe just configuring them as high impedance inputs is already good enough and you can then make those pins part of your guard net. (the guard tracks are (should be) driven by a fairly low output impedance).