Only 2M? Don't worry about it. You need to clean that assembly well anyway, if you want to maintain the low supply consumption you're expecting. If you've got gigohms or ppm accuracy on the table, and less pressure for low supply consumption, give guarding some consideration again.
But say for academic purposes we wanted to consider it anyway: what we'd do is of course place the guard trace, with removed soldermask, around the nodes in question (mind this is pretty much impossible on DFN/SON and CSP types; should be doable with the SOT version), then bias it to something nearby, which would indeed have to be an external reference source or voltage divider in this case. You could do a TLV431 (or there are lower current references in similar voltages), another voltage divider (with probably around the same resistances), or add on a buffer op-amp to bootstrap it (the priciest but most precise option).
Tim