All signals follow both the path of least impedance and path of least inductance, the faster the transition speed, the more it preferences the path of least impedance.
This is why you tend to see analog and digital segments grouped by function, to keep currents from one segment overlapping another, you do not have to go as far as is-landing the analog segment on its own plane in most cases, just try and keep the overlap to a minimum.
Now breaks / islands in a ground plane are OK, as long as no signals cross the break and there is no large currents flowing along either side of the break, not following these 2 points will turn the break into an antenna, the larger the detour a signal has to take from its path of least impedance, the more noise it will emit, which may then be coupled back into your analog segment that you separated in hopes of preventing.
If you treat all signals as loops, it is easier to visualize what may become a problem, so a digital signal from your ADC feeds a bit of current out to your micro, this current will continue back through the micro, down its ground pin, and back through the ground plane the ADC's ground pin, completing its loop somewhere inside the ADC.