These machines are best suited to RF research work and I've used T-Tech and LPKF machines since the 1990s and I think that no serious RF design lab should be without one. They are simply brilliant for designing oneoff prototypes for RF filters, oscillators or other smallish test circuits.
Nothing else competes on time, cost and versatility for RF board design because you can mill a suite of simple circuit designs on any laminate you choose in under an hour. i.e. design it on a PC, then mill it and then test it in a morning.
I've got a couple of T-tech machines here at home and we use an old LPKF machine at work.
However, I don't think they are suitable for general purpose PCBs using FR4 and they are at their worst if you want to mill a large board with lots of digital components. It takes ages to mill all the tracks and it isn't cost effective.
Therefore, the key to success with these machines is to be milling small and simple RF PCBs on exotic PCB laminates, especially if you want a PCB with a non rectangular outline. They are also useful for making laminated tools or for making simple front panels.
Like I said, nothing else can compete for the kind of work I do. But if I wanted to make a few MCU based boards that were fairly large and complex and I wanted a decent service life from the board and I wasn't in a rush for the boards then I'd just order the PCBs from a cheap PCB manufacturing house like most people do

The T-Tech or LPKF milling machines can't really compete here unless you absolutely needed the PCB the same day and were willing to spend an hour or two milling it and put up with the lack of proper PTHs and lack of solder mask etc etc.
You can also buy them cheaply if you are brave and buy an old/ used T-Tech 7000S machine. I bought my first one maybe 12 years ago for about £800 complete with tools and materials and Nilfisk extraction system and bought a second one (albeit with worn bearings) for about £600 a few years later. This also had tools and materials and a Nilfisk extraction system.
The first one paid for itself within months because I milled a series of RF filters on Rogers material for a local company and they paid me £70 per PCB for a same day service.
