Is this advisable to copy?
That is the reference design from the nRF datasheet, so yes, copy all layers as verbatim as possible. There are more factors at play. That design is coming from a company that sell billions of RF chips since many generation of nRF devices. I expect their PCB design was already optimized for best performance and least EMI.
I'm not sure I understood your argument for not following the reference design, but you can try 2 small batches, one with the cut and the other with solid layer, and compare their EMI performance.
My bet is the reference design will work much better as it is, than without that cutout.
In general, the energy is in the space between the going and the return wire, never in the wire (or the copper plane itself), so the nearby layers and the vias between layers matters the most. (I'm talking in the spirit of this video, it's a long one but it worth a watch:
https://www.eevblog.com/forum/chat/fun-for-nerds/msg5583117/#msg5583117If Rick Hartley's guidelines seem strange, see the book "Fast Circuit Boards" by Ralph Morrison, where it is explained the physics behind those PCB decisions.