I'm just a hobbyist and don't deal with high frequencies. I generally route everything except VCC and GND first. In fact, I tend to hide those airwires. Once signals are done, placement is very important, I turn to VCC and make adjustments, if reasonable. Finally I do ground usually as a pour. VCC can be kept direct and wide on the bottom layer. I am sure others may disagree, but my boards have have worked OK for me.