Well that is a good question, I can't give you the answer to that. There are many factors that contribute to things like skew, reflections and cross talk and they all add up.
I can give you the answer to that.

The coupling between adjacent traces within a layer, is typically small, less than 30%. (I have to use "typical" here, because the board stackup is not specified. If stackup, material, and trace width measurements were provided, the equivalent circuit could be solved for.)
So, if one trace has a full logic step, even if it's directly adjacent to another, the amount of induced interference is only about that much -- 30% of the full step, or whatever.
Crosstalk drops rapidly with separation, so that, say, 20 mils away from a 7 mil trace, in a 10 mil stackup, will be more like, uh, 5 or 10% I think. (I don't have the numbers handy -- I'm pulling these out of my ass -- but they are easily solved for with a coupled-line calculator. Search for one!

) That's enough to upset timing in a critical interface (you wouldn't want to run your RF synchronizer clock through here), but well within the capability of a typical commodity serial bus!
And as I said above, length matching is the more critical factor -- if a pair is routed from point A to point B, and ends up going through a few bends, the innermost trace will have less length than the other, and so
must make a small loop somewhere to take up that difference. Preferably, this happens at the corner, preserving the condition I gave above (lengths matched throughout the route).
Interference is also a length-dependent thing. A length-tuning feature nearly touching another trace won't introduce much interference, it's probably a small fraction of the wavefront (the length of the wavefront being, the signal's risetime as it appears in space, moving at the speed of light). If they were routed poorly so that there's a long stretch of proximity, there will be much more crosstalk, up to the full coupled amount (give or take frequency content, because of resonant effects of coupled lines).
So no, for almost all cases, don't worry about it, prioritize the other things. Don't ignore these aspects, of course, but don't compromise higher priority aspects!
Cheers,
Tim