That said, if you can reverse-engineer those Virtex-5 boards at least enough to make use of them, they can still be interesting to play with. Virtex-5 FPGAs are still pretty powerful stuff. The one on those boards is not the biggest Vritex-5 available though, of course.
If you only intend to use them as an "accelerator" of some kind, and only need the PCIe interface as far as IOs go, then it's probably rather straightforward. It's very likely the vendor used Xilinx PCIe IP for this, and thus probably used a documented pin-out for the IOs for PCIe. So there's possibly nothing much to reverse engineer if you don't need access to any other IO and just use Xilinx IP for PCIe.
There doesn't seem to be any external memory on those boards though, so if you need lots of memory, just forget about it. But if the internal block RAM is enough for your projects, then why not.
Certainly the Arria 10 boards are more powerful stuff and include DDR4 RAM. But of course, significantly more expensive. I also don't know if you can easily get ahold of the documentation.