I've got a system built with an Asus X79-Deluxe motherboard and a Seasonic Platinum PSU. It has an Intel Core i7, 64 GB of DDR3 RAM, and a Samsung SSD as the C: drive.
I left the system running overnight last Saturday and when I went to use it Sunday afternoon it appeared to be powered off. The power switch on the computer's case had no effect--the fans didn't start spinning and there was no output on either of the two monitors. I verified that the wall outlet it was plugged into had power (it did).
I disconnected all external peripherals (monitors, keyboard, mouse, Ethernet, and speaker) and tried again. Still nothing.
I opened the case up and noticed that the power button on the motherboard itself was lit (as was the reset button next to it). This indicated that the system was getting some power from the PSU. I tried pressing the power switch on the motherboard and that didn't have any effect. I next tried resetting the CMOS (by holding down the "reset CMOS" button on the MB while pressing the power switch, but that had no effect either.
Is this issue likely to be a power supply issue or a motherboard issue? Unfortunately, I don't have a spare PSU lying around that I can try. I'm hoping that it's the PSU, though, as that would be much easier to replace than the motherboard.