Only if CAN interfaces become as common on microcontrollers as UARTs are now. I would say there's a better chance of USB OTG replacing UART, but UART has the simplicity that others don't.
There are a lot of Freescale MPUs that come with an embedded CAN, also there are a some good and cheap SPI-CAN chip. So, it seems possible.
Other potential alternatives would be I2C and SPI
Both my Japanese PDA and laptop come with I2c and SPI. The laptop also has CAN, "RS232-4W"(1), I2C and SPI; however, I2C and SPI are only used internally(2), there is a little connector under the plastic, you can somehow access it, but you cannot connect a cable longer than 20cm, and that's the point! CAN and RS232 can be used with long cables! Even longer than 1m.
(1) "RS232-4W" means { 3.3V, TX, RX, GND }, it's sometimes routed to a RJ12/4pin (usually with routers)
(2) there are several SPI channels, one connects the boot flash, that contains u-boot.
I2C and I2S are used to connect the touchscreen chip, and the sound chip, but there is a fourth channel not used, routed to a small connector.