I am no expert. Until someone who has more concise answers, this may give you a starting point:
I suspect some support stuff in the middle that iTune is relying on is missing. I would suspect something like directX, QuickTime, or something like that. QuickTime is Apple stuff, so between directX and quicktime, try installing quicktime and then reinstall iTune again if needed.
Also, if you could find older versions, get iTune of the Xp-Sp3 era instead of much later iTune that says it support Xp.