Roughy without any Cooling holes over a coffee for a look as I already had the ITX board modeled from the first one.
Acrylic this time, no final idea how all the bits will get held together (glue, screws or a combination). Overall dimensions 200x200x70 and still should have room for a 2 1/2" drive if needed.
edit - just about finalised the design so a render with some more detail added.