I'm a bit paranoid when it comes to installing random stuff on my PC. I hate it when I have to install some piece of software of dubious quality for a one-off job. Even after uninstalling it, I can often find it's left some dependencies behind or otherwise messed with my system in one minor way or another. That's why I love "Windows Sandbox" - a feature recently introduced in Windows 10 Pro build 1903. It relies on Hyper-V virtualization and basically is a clean, disposable Windows 10 installation within your main Windows 10 installation. You can launch it, install some dodgy software in it, play around with it for a bit. When you close your Sandbox windows, it nukes all the changes made to its underlying virtual disk and wipes itself clean.
What I missed with this solution alone was inability to use physical USB devices within Windows Sandbox. Some other virtualization platforms like VirtualBox do offer USB pass-through but Windows Sandbox and its underlying Hyper-V hypervisor doesn't. The way to solve it is to use a third party "USB over IP" software solution. I noticed something called "VirtualHere" available for install on my Synology NAS. Tried it out and it's awesome. Now I can attach a USB device to my Synology's USB port, launch Windows Sandbox on my PC, install VirtualHere Client there and "attach" remote USB device there. Now the OS inside Sandbox behaves as if there was a physical USB device connected to its virtual USB hub exposed by the VirtualHere client. This completes my "throwaway", no-trace-left solution for one-off, disposable USB devices' software installations.
I've already performed a HDD test using the vendor-provided, proprietary disk testing software that I was reluctant to install on my main "productive" OS. Also, as I write this, I'm updating a TomTom SatNav device. Their software installs a virtual network adapter (NDIS over USB) for talking to the SatNav device but after I'm done, I'll just close the Windows Sandbox and there'll be zero footprint left behind.
I see a great potential in that, for instance when you have to use this dodgy piece of programmer software of dubious provenience for some obscure chip that you just need to use this one time.