As with any major version upgrade, it will make your projects and libraries incompatible with v6. Obvious, but something to think about if you're collaborating with people who may have not upgraded. Do not rush it and plan, if that's your case.
For hobbyist use, of course it usually doesn't matter.
Otherwise, 7.0.1 fixes a sizable list of bugs so that's a much better bet than 7.0.0.
Still a few annoying quirks. One of them that I mentioned is that navigating hierarchical sheets has become much slower than in v6. But you get a sheet navigator. Switching sheets (unless they are practically empty, it worsens with the number of symbols and connections) takes in the order of 1s in v7 (it's an order, will of course depend on your computer), while it was much faster in v6. While many people don't seem to care much, I find it pretty annoying and it's been confirmed, so improvements should end up in a future release. Apparently, the development branch 7.99 already has improvements. Of course, for those who don't even use hierachical sheets, it doesn't matter.
I otherwise like the new features in the schematic editor, and also the "complete trace route" feature in the pcb editor, something I had been waiting for. The initial footprint placement has also been improved, so that should all make layouting more productive.