I did not mean that I tweak the positions, just all the other things. Like I got some tapes where the parts were rotated 90deg from the last few times I ran the same parts. There are other little things, that need checking and small changes. Any new parts that have not yet been defined have to be entered. So far, in 18 months, I have not yet set up a new design that did not have something that needed some attention.
In relative terms, I am new to P&P and still have a lot to learn. So far, I have figured out how to automate the programming so I never have to do any of that manual. I also (recently) synchronized our internal part numbers with the CAD system so that it is a few keystrokes to get from design to a programmed machine. If faced with 4 boards that are 300 parts - I would certainly setup the machine for it. Not sure how many unique parts you are talking about, but I doubt I could get the machine placement ready in an hour. By the time I find/organize parts, load a feeder and verify with the BOM, theta noted, etc....it seems to be about 5mins per part (loading the feeder is maybe 90 seconds). Then I get them in the machine, and verify that I did not swap the 100nf and 10nf caps, which of course is an easy mistake. So 20 parts, programming, checking, verify - maybe 2-3hrs at my current speed for the 1st board.