AFAIK the only real issue is registration, and that can be solved by
Have you ever done it? What kind of laminator are you using?
The real problem with boards this big is the thermal conductivity of copper. If your laminator can do a board like this, no problem, then it's a beast.
I do boards 15cm x 23cm, all the time. (9" x 6" on my side of the pond.) I took the laminator out of the plastic case and screwed it to a plank of wood. Then I shoot the board with a 1200W heat gun as it goes through the preheat. Then transfer it with no air. Then I do it one more time while shooting it with the heat gun. For a double-sided board, same deal. I shoot directly over the (dextrin) paper, AFTER it has been tacked to the board with no air.
For a board this big, I'm using full power on the heat gun and kinda waving it back and forth in a consistent manner, right where the board enters the laminator. For smaller boards, you can definitely overdo this and even get the toner to burn.
I know when it's hot enough when the board is too hot to handle by anything but the edge, when it comes out the other side. It's like cooking. It takes a little trial and error. And cooking a 20 lb turkey takes longer than reheating a tray of taquitos. With a thick copper pour, it might even take more than one pass.
For a board this size, I really doubt you can do this consistently without dextrin coated paper and a pre-etch on the copper clad. It makes a huge difference in the quality, and you can't skimp on a board this large. 95% yield on a small board might be <50% yield on a large board. As you go up in size, it pays big-time to go the extra mile on the finer details. Scrubbing and re-doing a board is a lot of time and effort that is wasted. I have probably done my last 50 boards in a row with maybe only one minor mishap (salvageable) when I got particularly sloppy. I have no affiliation with Pulsar dextrin-coated toner transfer paper, but I will highly recommend it. It saves me more time than it costs. I'd probably still be buying it if it cost 5x as much. And I used to buy PnP "blue" by the 100 pack. Still have 30-40 sheets of it left, and it's not even worth my time to use it up. I really hate buying Pulsar in 5+ 10 packs at a time, though. They really need to do a bulk size, lol. I'm paying as much for the packing as the paper, I'm sure.
FWIW, my laminator is called a GBC Creative. I have been using my first one for about 6 years, now. The only other modification was to take it apart to egg out the holes for the top roller, to allow room for a full 0.062" board + two thickness of transfer paper without skipping teeth on the gearing. The spring contact still presses on thinner boards. I do 0.007" boards on the same laminator with no problem.
To save time and money, I precut a lot of it into 4x3" squares, a bunch at a time, tape those to printer paper, and load them into a dedicated pcb printer, ready to go for my smaller protos. If my pcb is smaller than that, oh well.. I can do a small panel or I can just waste the extra paper. I used to make at least 4 of a pcb in my pre-Pulsar days, just in case one came out wrong. But those days are gone.