On full scale airplanes there are various ways to secure fasteners. Serrated washers and washer-head nuts and bolts can be used. In critical areas, locking nuts and safety wires are used. Depending on function, lock nuts can be nylon/fiber inserts or deformed thread. The latter is required in high temperature areas. Thread locking compounds, e.g., Loctite, can also be used as a substitute according to specifications/regulations.
I do not like serrated fasteners because they mar the surfaces to which they are attached. They might be fine where periodic disassembly is not needed. When such disassembly is needed, I prefer safety wiring or one of the other alternatives.
For any soft material, like wood or plastic, I would never use a serrated fastener.* For your electric motor mounts, nylon insert, distorted thread, or thread locker is probably OK. In cars, you see a lot of liquid thread locker and distorted thread used. Be aware there are generally 2 types of liquid thread locker. One type sets firm but can still be unfastened relatively easily. The other sets hard and is more difficult to remove without heat.
For IC engine mounts against wood in my model airplanes, I use safety wire. They may get loose, but they never come apart.
*A flanged, e.g, washer-headed, but not serrated fastener increases the contact surface area and offers some protection. I use them on wood too.