Guys, you are making this out to be a difficult problem, and it really isn't! Achieving 1uA FSD using a JFET-input op-amp like the OPA1641 is trivial. You can pretty well rely on a JFET having gate leakage current of <2pA, so that's not going to upset a 1uA FSD meter. Input voltage offset is not amplified by an electrometer, so you're likely to see a 2mV or thereabouts offset on the output for an instrument that will develop 10V at FSD, so that's 0.02% error at full scale and can be tweaked out if necessary. The biggest error comes from the current conversion resistor, but 10M is easily available in 0.1% tolerance and could be trimmed if necessary. In short, it's a simple problem, easily solved. You could add input protection and make it more complex or you could make it easy to replace the (cheap) op-amp.
If you want 1nA FSD, you'll need a 10G current conversion resistor, available in 1% tolerance at best, so the <2pA gate leakage current is still less than the error from the current conversion resistor. But you will need to be careful about cleanliness with that large a resistance.