use mechanical chopper, or stock CMOS part?
Mechanical chopper isn't suitable (e.g. this isn't for nanovoltmeter or chopper amplifier). No stock CMOS parts fit the requirements.
MOSFET+PHOTOVOLTAIC (FDA217)
Along similar lines to my initial sketch except that a simple implementation like this has too much leakage (hence all the extra circuitry in my sketch).
The concept can work in principle, but with so many parts in series in the signal path the possible thermal EMF parts can add up.
I agree, it's why I wanted separate optocoupler. Then the only consideration is dynamic switching losses that creates heat in the gate. Maybe there are more considerations? Desirable maximum switching frequency is 100Hz but it's likely that this will be less if switching losses causes unacceptable thermal EMF.
About op-amp, I'd probably be looking at AD8641 which maintains acceptable input bias current in 20-50 degC range.
You'll notice that I'm trying to eliminate leakage on both relay terminals as the end application isn't ground referenced on either terminal, hence why there are so many parts.
If this relay is possible then I'm considering a cutkosky divider, that might help you understand the requirement for low RDS on.
But i think there are maybe only a handful of COTS solid state relays that would achieve the difficult <0.01R spec.
I had a look around and some of the COTS SSRs came close to requirements but not quite there. AQV252G2S looks good for a less-demanding requirement.
I use Omron G3VM-41BR.
Thanks, that is a nice part that comes close to requirements. I am concerned about thermal EMF & leakage, I think I may have to measure this part to see how conservative the datasheet is.