I'm having a lot of trouble finding a 16-bit USB interface.
If you need speed, the FX2 mentioned above is fast, and has low cost modules.
If you need lowest price for volumes, then a small MCU is better.
PIC16F1459 mentioned above is Microchip 8b offering.
Similar, but cheaper are SiLabs EFM8UB1 (64c/3k) or EFM8UB3 (93c/3k)