Well, I was looking at CH348 (high speed USB to Octal Serial Ports) and didn't thinking in direction that they (WCH) probably have IP hardware part (high speed USB with more than 8 endpoints) that is included in their microcontrollers.
Now (thanks to XIVN) AFAIK, WCH is only device with HS USB module with 16 bidirectional endpoints, and FS USB too. Unfortunately they don't have SPI with 4 data lines (and I need this).
Kinetis K26 and K66 are with 16 bidirectional endpoints in FS USB module. HS USB is limited to 8, like in most micros today.
I am working on K32L2A (KL28 remake) that have all that I need. Searching few days over mouser and digikey, for same but more horse power and HS USB, ended without result.
Just to comment IMXRT. I was also thinking about 2 HS USB module inside micro bridged with extra USB HUB chip on board. IMXRT need extra flash chip, half of the pins are not GPIO, there is special power on/off sequence and there is no DAC (except 1170). Not for me.