D20 is the first Cortex-M0+ product from Atmel. A lot of lessons have been learned, a lot of things have been improved since then. D20 feels somewhat different from all following Cortex-M0+ devices.
It is not a bad device, some things are just a bit weird feeling. Some registers have strange bit assignments, this sort of stuff. Nothing you can't live with, but D21 is more polished, includes a lot of improvements based on feedback from the D20.
Option for USB is also nice. It is extremely easy to use and requires no external components (not even a crystal).