I would avoid prolific.
I've used several cheapo cables with these devices, and whilst they could easily have been counterfeit devices, it was a pain. It could cause the PC to freeze, but mostly just the driver crashed requiring an unplugging/plugging cycle.
the CP2102 seems very stable on win7,8.1 and 10.
Failing that, I'm a fanboy of the PIC16F1455. Probably overkill, but occasionally using a micro you have full control over (rather than a permanently programmed micro like these other devices) means you can load off some tasks from other systems. There are a few examples of USB-serial bridges with it where you can add your own code for anything else you need. Otherwise its just a case of flashing it and it works (never had issue with them).