Spartan3 works fine on Win10, the operating system is not an issue, you just need the right version of ISE. The popular Papilio One FPGA board uses the same FPGA in a smaller package with fewer pins. You should be able to run any of the arcade cores on there, Pacman, Galaxian, Frogger, etc. That FPGA is big enough to hold the ROMs internally and you've got that nice big SRAM which should be good for retro computer projects and such. Looks like a nice little board.