That is incredibly dependent on the microcontroller family chosen. Many have special requirements.
However there are a few common factors:
* Ground plane - don't try to do without it if there are external signals with less than 1us between edges. You may be able to get it to work with faster signals without one but its not good practice.
* Connect *ALL* supply and ground pins unless the datasheet says otherwise - internal power bus metalisation between different sections of the chip is often not sized to carry the full rated supply current.
* Decouple *ALL* Vdd supply pins as close to the pin as possible.
* Keep supply tracks short and wide - don't snake one round the board edge to avoid a wire link or a few vias.
* Keep any external crystal connections close to the chip and clear of other signals.
For the rest, if there is a manufacturer's demo board or reference design, STUDY IT, otherwise study the datasheet till you can quote it in your sleep!