Yes, now the OP said the writes would not be frequent (define frequent here?). Say the flash area for these settings is written to 1 time per day. 10000 cycles min would be 27 years.
Not sure it would be worth fretting about, but if the OP intends to make a product with a PY32F002B planned to have a > 27 years lifetime, that's interesting.
Or, again, if unsure, just use a small external EEPROM which are very cheap in those small sizes, and call it a day.