Are you sure about that? It looks like labels are swapped either here or on the schematic. R3 is Pin46 and DM according to the schematic. This is the left resistor.
But the actual routing is correct. So, it must be some mixup with the labels.
Your next step is to figure out why PicoProbe does not work. There seems to be something really wrong with your computer.
You can even do the experiment with the resistor and you should see USB traffic, at least the SOFs and a request for the device descriptor.