think clk is normally not 'bundled' in RS485 implementations and that clk & 'synchronous' is probably some "propriety" phy and protocols.
as i didn't work much with RS485, hence, I'd leave it at that.
for 'simple' implementations, i'd just use a uart to interface it.
async 'clock recovery' is 'difficult' and hence I'd guess the designers just made it 'synchronous' by putting a clk line, but that clk on its own can also be noisy or be slew limited (long lines practically work like rlc filters) and possibly limit the distance/length possible.
I think differential signalling
https://en.wikipedia.org/wiki/Differential_signallingworks like flipping the battery between the +/- signals forward and reverse literally. Hence, it is possibly 'easier' to use a transceiver e.g. rs485 / rs422 to translate the signals back to the 'normal' 0 and 1 signals.